The purpose of the study is to increase our understanding of the long term effects of trumatic brain injury on service members and veterans. Participation will include short yearly appointments. Each visit will last either 2 hours or 2 days and will occure once per year for up to 15 years. You may elect to participate only in web-based and telephone measures.
Your participant could contribute to knowledge that could improve the care of your fellow service members and veterans. You may be compensated for your participation.
http://www.Clinitical Trials.gov (NCT01045226)
Active Comparator: Arm I: Patients receive cisplatin IV over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.
Experimental: Arm I: Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30-60 minutes on day 1.